I think I know the perfect candidate for that "Despondex". There is a woman that worked several desks over from where I was located who had a high pitched loud voice to begin with. She was one of those super cheerful persons, no matter whether it was first thing in the morning on Mondays or the last thing on Friday afternoon.

For a while it was just plain annoying, but as the years went on, thoughts of strangulation became more and more frequent.